Glycyrrhiza Glabra

Glycyrrhiza Glabra (Licorice Extract)

Licorice Extract is derived from a group of perennial flowering shrubs with horizontal underground stems (rhizomes) known as the genus Glycyrrhiza.

In India it is known as Mulethi and Yashtimadhu in Indian Ayurveda. The roots and rhizomes of Licorice (Glycyrrhiza glabra Linn; family: Leguminosae) have been in traditional use for several centuries

Applications

•Food & Confectionery
•Beverages
•Tobacco
•Pharmaceuticals

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Glycerrhizin acid – 10 – 25 %
Glabridin – 6%

Molecular Structure of Actives

Active Pharma Ingredients

  • Glycyrrhizin or Glycyrrhizinic Acid
  • Glabridin
  • Glabrene
  • Glabrol
  • Licoflavonol
  • Glycerol
  • Licoricone
  • Formononetin
  • Phaseollinisoflavan
  • Hispaglabridin A and B
  • 3-Hydroxy Glabrol
  • 3-Methoxy Glabridin
  • Glabranin isomer
  • Narigenin & Lupiwightenone

Functional Dyspepsia Treatment

  • Glycyrrhizic Acid can suppress the toxic bacteria H. pylori, and can prevent it from growing in the gut.
  • The general symptoms of functional dyspepsia include upper abdominal fullness, Epigastric pain, belching, bloating, early satiety, nausea, vomiting, regurgitation, heartburn, and loss of appetite
  • Researches show that DGL is also used as a main source for the treatment of ulcerative conditions of gastrointestinal disorders like peptic ulcer, canker sores, inflammatory bowel diseases.
  • The antiulcer property of Licorice extract was also established in gastric ulcer patients.

Pharmacological Activities

  • Extract obtained from Licorice Roots exhibit Expectorant,
  • Diuretic
  • Laxative
  • Sedative
  • antipyretic
  • antimicrobial
  • hepatoprotective
  • antioxidant
  • antiadhesive properties

References
1. Holtmann G, Talley NJ, Liebregts T, Adam B, Parow C. A placebo-controlled trial of itopride in functional dyspepsia. The New England Journal of Medicine. 2006;354(8):832–840
2. Adam B, Liebregts T, Saadat-Gilani K, Vinson B, Holtmann G. Validation of the gastrointestinal symptom score for the assessment of symptoms in patients with functional dyspepsia. Alimentary Pharmacology and Therapeutics. 2005;22(4):357–363Zhang Q,2019
3. Murray MT, Pizzorno JE., Jr. Glycyrrhiza glabra. In: Murray MT, Pizzorno JE Jr., editors. Textbook of Natural Medicine. 2nd edition. London, UK: Churchill Livingstone; 1999. pp. 767–773
4. Hikino H. Recent research on oriental medicinal plants. In: Wagner H, Hikino H, Farnsworth NR, editors. Economic and Medicinal Plant Research. London: Academic Press; 1985. pp. 53–85.

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